Hydrochloric Acid → (S)-2-(2-(Methoxymethyl)pyrrolidin-1-yl)ethanamine

HRID 335337노트

반응식

HRID 335337 반응식
[CH3:1][O:2][CH2:3][C@@H:4]1[CH2:8][CH2:7][CH2:6][N:5]1[CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C.Cl>CO>[CH3:1][O:2][CH2:3][C@@H:4]1[CH2:8][CH2:7][CH2:6][N:5]1[CH2:9][CH2:10][NH2:11]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 71283522(S)-tert-Butyl 2-(2-(methoxymethyl)pyrrolidin-1-yl)ethylcarbamate

생성물 1

HCID 57639942(S)-2-(2-(Methoxymethyl)pyrrolidin-1-yl)ethanamine

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

A solution of (S)-tert-butyl 2-(2-(methoxymethyl)pyrrolidin-1-yl)ethylcarbamate (step 1) (1.89 g, 7.32 mmol) and in MeOH (5 ml) and treated with 2M HCl in MeOH (10 equivalents) at room temperature over the weekend. The solvent was removed in vacuo to afford the title compound;

후처리

  1. customThe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-1c802c2680ba4f128f90f4fbd50fe2b7
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883819B2

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