Water → 6-(2-Fluoro-4-trifluoromethyl-phenyl)-2-methyl-3-[3-methyl-4-(4-[1,2,3]triazol-1-yl-butyl)-phenoxymethyl]-pyridine

HRID 33546노트

반응식

HRID 33546 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([OH:17])[CH:5]=[CH:6][C:7]=1[CH2:8][CH2:9][CH2:10][CH2:11][N:12]1[CH:16]=[CH:15][N:14]=[N:13]1.[H-].[Na+].Cl[CH2:21][C:22]1[C:23]([CH3:39])=[N:24][C:25]([C:28]2[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:36])[F:35])=[CH:30][C:29]=2[F:38])=[CH:26][CH:27]=1.O>CN(C)C=O>[F:38][C:29]1[CH:30]=[C:31]([C:34]([F:36])([F:37])[F:35])[CH:32]=[CH:33][C:28]=1[C:25]1[N:24]=[C:23]([CH3:39])[C:22]([CH2:21][O:17][C:4]2[CH:5]=[CH:6][C:7]([CH2:8][CH2:9][CH2:10][CH2:11][N:12]3[CH:16]=[CH:15][N:14]=[N:13]3)=[C:2]([CH3:1])[CH:3]=2)=[CH:27][CH:26]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 24758Sodium hydrideHCID 69106508HCID 69106508, 화합물HCID 691096663-Methyl-4-(4-[1,2,3]triazol-1-yl-butyl)phenol

생성물 1

HCID 160653046-(2-Fluoro-4-trifluoromethyl-phenyl)-2-methyl-3-[3-methyl-4-(4-[1,2,3]triazol-1-yl-butyl)-phenoxymethyl]-pyridine수율 76%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
0 °C

실험 절차

A solution of 153 mg (0.66 mmol) 3-methyl-4-(4-[1,2,3]triazol-1-yl-butyl)phenol in 8.0 ml N,N-dimethylformamide was treated at 0° C. with 26 mg (0.66 mmol) of 60% sodium hydride and stirred at 0° C. for 30 min. Then 200 mg (0.66 mmol) 3-Chloromethyl-6-(2-fluoro-4-trifluoromethyl-phenyl)-2-methyl-pyridine were added and stirred continued at r. t. over night. After addition of 16 ml water, the precipitate was isolated, washed thoroughly with water and diisopropylether. The residue was dried at 40° C. to give 250 mg (76%) of the title compound as light brown powder.

후처리

  1. stirringstirred
  2. waitover night
  3. customthe precipitate was isolated
  4. washwashed thoroughly with water and diisopropylether
  5. customThe residue was dried at 40° C.

출처 및 근거

ORD 기록
ord-14cd45f37c694cc88052a057ffa1e8b9
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429605B2

반응 노트

불러오는 중…