1-[(4-fluorophenyl)methyl]-4-methoxy-2-methyl-1H-indole → 1-[(4-fluorophenyl)methyl]-4-hydroxy-2-methyl-1H-indole

반응식

[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]2[C:17]3[C:12](=[C:13]([O:18]C)[CH:14]=[CH:15][CH:16]=3)[CH:11]=[C:10]2[CH3:20])=[CH:4][CH:3]=1.B(Br)(Br)Br.C(Cl)Cl>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][N:9]2[C:17]3[C:12](=[C:13]([OH:18])[CH:14]=[CH:15][CH:16]=3)[CH:11]=[C:10]2[CH3:20])=[CH:6][CH:7]=1

참가 물질

반응물 2

HCID 108258491-[(4-fluorophenyl)methyl]-4-methoxy-2-methyl-1H-indole

HCID 22277759Boron tribromide dichloromethane

생성물 1

HCID 107535031-[(4-fluorophenyl)methyl]-4-hydroxy-2-methyl-1H-indole수율 84.2%

실험 절차

By the method used in Example 1, Part D, 1.1 g (4.1 mmol) of 1-[(4-fluorophenyl)methyl]-4-methoxy-2-methyl-1H-indole was O-demethylated by treating it with 16.4 mL of 1M BBr3 /CH2Cl2 to give 881 mg (84% yield) of crude 1-[(4-fluorophenyl)methyl]-4-hydroxy-2-methyl-1H-indole.

출처 및 근거

ORD 기록: ord-858e366b919f470e923529fff24917ea
출처 데이터셋: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05733923

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