Methyl Thioglycolate → Methyl 5-fluoro-1-benzothiophene-2-carboxylate

HRID 335561노트

반응식

HRID 335561 반응식
F[C:2]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:3]=1[CH:4]=O.[H-].[Na+].[SH:13][CH2:14][C:15]([O:17][CH3:18])=[O:16]>>[F:10][C:7]1[CH:8]=[CH:9][C:2]2[S:13][C:14]([C:15]([O:17][CH3:18])=[O:16])=[CH:4][C:3]=2[CH:6]=1

참가 물질

4

반응물 3

HCID 16907Methyl ThioglycolateHCID 24758Sodium hydrideHCID 1376632,5-Difluorobenzaldehyde

생성물 1

HCID 22473847Methyl 5-fluoro-1-benzothiophene-2-carboxylate

실험 절차

Using 5.0 g (35.2 mmol) of 2,5-difluorobenzaldehyde, 2.11 g (52.78 mmol) of sodium hydride (60% pure) and 4.11 g (38.7 mmol) of methyl mercaptoacetate, 1.1 g (14.3% of theory) of the title compound are obtained.

출처 및 근거

ORD 기록
ord-e54c5d5a95004392a18ce93aa2d0fc63
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08884017B2

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