Methyl Thioglycolate → Methyl 4-fluoro-1-benzothiophene-2-carboxylate

HRID 335562

반응식

HRID 335562 반응식
F[C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[CH:4]=O.[H-].[Na+].[SH:13][CH2:14][C:15]([O:17][CH3:18])=[O:16]>>[F:10][C:6]1[C:3]2[CH:4]=[C:14]([C:15]([O:17][CH3:18])=[O:16])[S:13][C:2]=2[CH:9]=[CH:8][CH:7]=1

참가 물질

4

반응물 3

HCID 16907Methyl ThioglycolateHCID 24758Sodium hydrideHCID 1362842,6-Difluorobenzaldehyde

생성물 1

HCID 2783209Methyl 4-fluoro-1-benzothiophene-2-carboxylate

실험 절차

Using 5.0 g (35.2 mmol) of 2,6-difluorobenzaldehyde, 2.11 g (52.8 mmol) of sodium hydride (60% pure) and 4.11 g (38.7 mmol) of methyl mercaptoacetate, 5.61 g (72.8% of theory) of the title compound are obtained.

출처 및 근거

ORD 기록
ord-70cbc96ae4ae421da1af4628bb03c90b
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08884017B2

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