Methyl Thioglycolate → 5,7-Difluoro-benzo[B]thiophene-2-carboxylic acid methyl ester

HRID 335563노트

반응식

HRID 335563 반응식
F[C:2]1[C:9]([F:10])=[CH:8][C:7]([F:11])=[CH:6][C:3]=1[CH:4]=O.[H-].[Na+].[SH:14][CH2:15][C:16]([O:18][CH3:19])=[O:17]>>[F:11][C:7]1[CH:8]=[C:9]([F:10])[C:2]2[S:14][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:4][C:3]=2[CH:6]=1

참가 물질

4

반응물 3

HCID 16907Methyl ThioglycolateHCID 24758Sodium hydrideHCID 27769502,3,5-Trifluorobenzaldehyde

생성물 1

HCID 573508905,7-Difluoro-benzo[B]thiophene-2-carboxylic acid methyl ester

실험 절차

Using 3.94 g (24.6 mmol) of 2,3,5-trifluorobenzaldehyde, 1.48 g (36.9 mmol) of sodium hydride (60% pure) and 2.88 g (27.1 mmol) of methyl mercaptoacetate,

출처 및 근거

ORD 기록
ord-97fd5168b01b4cc6823644167562b3ef
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08884017B2

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