Methyl Thioglycolate → Methyl 6-cyanobenzo[b]thiophene-2-carboxylate

HRID 335565노트

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HRID 335565 반응식
Cl[C:2]1[C:9]([C:10]#[N:11])=[CH:8][CH:7]=[CH:6][C:3]=1C=O.[H-].[Na+].[SH:14][CH2:15][C:16]([O:18][CH3:19])=[O:17].[CH3:20]S(Cl)(=O)=O>C(OCC)(=O)C>[C:10]([C:9]1[CH:8]=[CH:7][C:6]2[CH:20]=[C:15]([C:16]([O:18][CH3:19])=[O:17])[S:14][C:3]=2[CH:2]=1)#[N:11]

참가 물질

6

반응물 4

HCID 16907Methyl ThioglycolateHCID 24758Sodium hydrideHCID 31297Methanesulfonyl chlorideHCID 119617032-Chloro-3-cyanobenzaldehyde

생성물 1

HCID 11031280Methyl 6-cyanobenzo[b]thiophene-2-carboxylate

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

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온도
80 °C

실험 절차

2.5 g (15.1 mmol) of 2-chloro-3-cyanobenzaldehyde are reacted according to the general procedure with 0.90 g (22.7 mmol) of sodium hydride (60% pure) and 1.76 g (16.6 mmol) of methyl mercaptoacetate. The resulting reaction product is initially purified by silica gel column chromatography (mobile phase: dichloromethane/methanol 100:1) and then dissolved in 30 ml of pyridine, and 650 μl (8.4 mmol) of methanesulfonyl chloride are added. The mixture is stirred at 80° C. for 2 h. After cooling, ethyl acetate is added and the mixture is washed twice with 1N hydrochloric acid and once with saturated sodium chloride solution, dried over sodium sulfate, concentrated and dried under high vacuum. This gives 1.63 g (49.9% of theory) of the title compound.

후처리

  1. customThe resulting reaction product
  2. customis initially purified by silica gel column chromatography (mobile phase: dichloromethane/methanol 100:1)
  3. dissolutiondissolved in 30 ml of pyridine
  4. temperatureAfter cooling
  5. washthe mixture is washed twice with 1N hydrochloric acid and once with saturated sodium chloride solution
  6. dry with materialdried over sodium sulfate
  7. concentrationconcentrated
  8. customdried under high vacuum

출처 및 근거

ORD 기록
ord-cadb99b348c0446fad0682c7241d51cb
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08884017B2

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