Phosphorus oxychloride → HCID 50914394, 화합물

반응식

[CH3:1][C:2]1([CH3:15])[O:6][C@@H:5]([CH2:7][C:8]2([S:11]([O-])(=[O:13])=[O:12])[CH2:10][CH2:9]2)[CH2:4][O:3]1.[Na+].P(Cl)(Cl)([Cl:19])=O>>[CH3:1][C:2]1([CH3:15])[O:6][C@@H:5]([CH2:7][C:8]2([S:11]([Cl:19])(=[O:13])=[O:12])[CH2:10][CH2:9]2)[CH2:4][O:3]1

참가 물질

반응물 2

HCID 24813Phosphorus oxychloride

HCID 86698215HCID 86698215, 화합물

생성물 1

HCID 50914394HCID 50914394, 화합물

실험 절차

A solution of sodium (S)-1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)cyclopropane-1-sulfonate (1 eq) and phosphoryl trichloride (POCl3, 0.7 mL/mmol) is heated at 80° C. for 1 hour. The reaction mixture is cooled to room temperature, poured onto ice, stirred for 30 minutes and extracted with chloroform (2×). The combined organic extracts are dried (MgSO4) and concentrated under reduced pressure.

후처리

additionpoured onto ice
extractionextracted with chloroform (2×)
dry with materialThe combined organic extracts are dried (MgSO4)
concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록: ord-dd96387118e541c6a5688cdabab2f899
출처 데이터셋: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08884058B2

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