Bromine → 2-Amino-5-bromo-3-fluorobenzoic acid hydrobromide
반응식
[Br:1]Br.[NH2:3][C:4]1[C:12]([F:13])=[CH:11][CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]>C(Cl)(Cl)Cl>[BrH:1].[NH2:3][C:4]1[C:12]([F:13])=[CH:11][C:10]([Br:1])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]참가 물질
4
실험 절차
Bromine (3.65 mL, 70.9 mmol) in Chloroform (250 mL) was added dropwise via an addition funnel to a suspension of 2-amino-3-fluorobenzoic acid (10 g, 64.5 mmol) in chloroform (400 mL) at RT. The solution was stirred for 12 hours at which point the resulting slurry was filtered. The solid was washed well with CH2Cl2 and dried under a stream of nitrogen to afford 2-amino-5-bromo-3-fluorobenzoic acid HBr.
후처리
- filtrationwas filtered
- washThe solid was washed well with CH2Cl2
- customdried under a stream of nitrogen
출처 및 근거
- ORD 기록
- ord-61abd4bdca784578aa19294a8726b651
- 출처 데이터셋
- uspto-grants-2014_11
- 특허 번호
- US08883782B2
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