Bromine → 2-Amino-5-bromo-3-fluorobenzoic acid hydrobromide

HRID 335876

반응식

HRID 335876 반응식
[Br:1]Br.[NH2:3][C:4]1[C:12]([F:13])=[CH:11][CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]>C(Cl)(Cl)Cl>[BrH:1].[NH2:3][C:4]1[C:12]([F:13])=[CH:11][C:10]([Br:1])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]

참가 물질

4

반응물 2

HCID 24408BromineHCID 5864082-Amino-3-fluorobenzoic acid

생성물 1

HCID 673836892-Amino-5-bromo-3-fluorobenzoic acid hydrobromide

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

Bromine (3.65 mL, 70.9 mmol) in Chloroform (250 mL) was added dropwise via an addition funnel to a suspension of 2-amino-3-fluorobenzoic acid (10 g, 64.5 mmol) in chloroform (400 mL) at RT. The solution was stirred for 12 hours at which point the resulting slurry was filtered. The solid was washed well with CH2Cl2 and dried under a stream of nitrogen to afford 2-amino-5-bromo-3-fluorobenzoic acid HBr.

후처리

  1. filtrationwas filtered
  2. washThe solid was washed well with CH2Cl2
  3. customdried under a stream of nitrogen

출처 및 근거

ORD 기록
ord-61abd4bdca784578aa19294a8726b651
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883782B2

연결된 노트

불러오는 중…