Bromine → 6-Bromo-2-fluoro-3-methoxybenzoic acid
반응식
[F:1][C:2]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Br:13]Br>C(O)(=O)C.O>[Br:13][C:7]1[C:3]([C:4]([OH:6])=[O:5])=[C:2]([F:1])[C:10]([O:11][CH3:12])=[CH:9][CH:8]=1참가 물질
5
반응 조건
- 온도
- 60 °C
실험 절차
To the suspension of 2-fluoro-3-methoxybenzoic acid (20 g, 118 mmol) in Acetic Acid (100 mL) and water (100 mL) at RT, bromine (12.05 mL, 235 mmol) was added dropwise. The reaction mixture was heated for 1 h at 60° C. The reaction was then cooled to RT and white precipitate was filtered. The solid was washed with excess water and dried to give 6-bromo-2-fluoro-3-methoxybenzoic acid (24.68 g, 99 mmol) as a white solid.
후처리
- temperatureThe reaction was then cooled to RT
- filtrationwhite precipitate was filtered
- washThe solid was washed with excess water
- customdried
출처 및 근거
- ORD 기록
- ord-5a2957c424af4dc5bd8f88bdb10436ce
- 출처 데이터셋
- uspto-grants-2014_11
- 특허 번호
- US08883782B2
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