Bromine → 6-Bromo-2-fluoro-3-methoxybenzoic acid

HRID 335974

반응식

HRID 335974 반응식
[F:1][C:2]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Br:13]Br>C(O)(=O)C.O>[Br:13][C:7]1[C:3]([C:4]([OH:6])=[O:5])=[C:2]([F:1])[C:10]([O:11][CH3:12])=[CH:9][CH:8]=1

참가 물질

5

반응물 2

HCID 24408BromineHCID 33906792-Fluoro-3-methoxybenzoic acid

생성물 1

HCID 534387896-Bromo-2-fluoro-3-methoxybenzoic acid수율 83.9%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 962Water용매

반응 조건

온도
60 °C

실험 절차

To the suspension of 2-fluoro-3-methoxybenzoic acid (20 g, 118 mmol) in Acetic Acid (100 mL) and water (100 mL) at RT, bromine (12.05 mL, 235 mmol) was added dropwise. The reaction mixture was heated for 1 h at 60° C. The reaction was then cooled to RT and white precipitate was filtered. The solid was washed with excess water and dried to give 6-bromo-2-fluoro-3-methoxybenzoic acid (24.68 g, 99 mmol) as a white solid.

후처리

  1. temperatureThe reaction was then cooled to RT
  2. filtrationwhite precipitate was filtered
  3. washThe solid was washed with excess water
  4. customdried

출처 및 근거

ORD 기록
ord-5a2957c424af4dc5bd8f88bdb10436ce
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883782B2

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