2-Methylpiperidine → 5-Methyl-6-(2-methylpiperidin-1-yl)nicotinonitrile
반응식
[C:1]([C:3]1[CH:4]=[C:5]([CH3:10])[C:6](F)=[N:7][CH:8]=1)#[N:2].[CH3:11][CH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][NH:13]1>>[CH3:10][C:5]1[C:6]([N:13]2[CH2:14][CH2:15][CH2:16][CH2:17][CH:12]2[CH3:11])=[N:7][CH:8]=[C:3]([CH:4]=1)[C:1]#[N:2]참가 물질
3
반응 조건
- 온도
- 90 °C
실험 절차
A mixture of 5-cyano-2-fluoro-3-methylpyridine (Molekula M52391889; 1.5 g; 11 mmol; 1 eq.) and 2-methylpiperidine (5.2 mL; 44.1 mmol; 4 eq.) was stirred at 90° C. for 16 hours.
출처 및 근거
- ORD 기록
- ord-8761c349e3134a7f85bf3a9876c2e5e3
- 출처 데이터셋
- uspto-grants-2014_11
- 특허 번호
- US08889668B2
반응 노트
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