Piperazine → 1-(4-Methoxypyridin-2-yl)piperazine

HRID 336360

반응식

HRID 336360 반응식
Cl[C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][N:3]=1.[NH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>CN1CCCC1=O.O>[CH3:9][O:8][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH:7]=1

참가 물질

5

반응물 2

HCID 4837PiperazineHCID 19911282-Chloro-4-methoxypyridine

생성물 1

HCID 226481321-(4-Methoxypyridin-2-yl)piperazine수율 16.2%

시약·촉매·용매 2

HCID 962Water용매HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

46 mg 2-chloro-4-methoxy-pyridine and 277 mg piperazine in 2 mL n-methyl-2-pyrrolidinone were stirred 45 min at 140° C. and 30 min at 200° C. under microwave conditions. The reaction was diluted with water and purified by HPLC to give 10 mg desired product.

후처리

  1. custompurified by HPLC

출처 및 근거

ORD 기록
ord-63fe068426d742b984b82fa0b5cd9a08
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889677B2

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