Piperazine → 1-(4-Ethoxy-pyridin-2-yl)-piperazine hydrochloride
반응식
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[Cl:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][CH3:16])[CH:11]=[CH:10][N:9]=1>C(O)CCC>[ClH:7].[CH2:15]([O:14][C:12]1[CH:11]=[CH:10][N:9]=[C:8]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)[CH:13]=1)[CH3:16]참가 물질
4
반응 조건
- 온도
- 115 °C
실험 절차
860 mg piperazine was added to 350 mg 2-chloro-4-ethoxy-pyridine in 3.5 mL n-butanol. The reaction was stirred 1.5 days at 115° C. The reaction was filtered and the filtrate was washed with water and evaporated. 1N HCl was added to the residue and the precpipate was filtered to give 238 mg of the desired product. Rt: 0.3 min (method B), (M+H)+: 208
후처리
- filtrationThe reaction was filtered
- washthe filtrate was washed with water
- customevaporated
- addition1N HCl was added to the residue
- filtrationthe precpipate was filtered
출처 및 근거
- ORD 기록
- ord-aa29e03f2d50462e8e58c5a4ee304661
- 출처 데이터셋
- uspto-grants-2014_11
- 특허 번호
- US08889677B2
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