참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Maleic Acid | HCID 444266 | — |
| 반응물 | Eszopiclone | HCID 969472 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | HCID 86633612 | HCID 86633612 | 76% |
반응 단계
A reactor was charged with 0.101 g (S)-zopiclone and 0.040 g maleic acid. The mixture was charged with 18 g ethanol, and agitated. The slurry was heated to 60° C. and aged for 90 minutes. The slurry was cooled to 20° C. and aged for 60 minutes. The reaction was filtered, washed once with 0.5 g ethanol, dried in vacuo at approximately 50° C. for approximately 6 hr, and provided the titled compound in 76% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08889685B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_11 |
|---|
| ORD ID | ord-0e8edbadd5694c8bbb6637ad37f09fe7 |
|---|
| 출처 메모 | uspto-grants-2014_11 |
|---|
