Tert-butyl 2-cyano-6-azaspiro[3.4]octane-6-carboxylate → tert-Butyl 2-(aminomethyl)-6-azaspiro[3.4]octane-6-carboxylate
반응식
[C:1]([CH:3]1[CH2:6][C:5]2([CH2:10][CH2:9][N:8]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:7]2)[CH2:4]1)#[N:2]>[Ni]>[NH2:2][CH2:1][CH:3]1[CH2:4][C:5]2([CH2:10][CH2:9][N:8]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:7]2)[CH2:6]1참가 물질
3
실험 절차
The process is performed according to the procedure described in Example 8 (step 8.2.). Starting with 0.20 g (0.85 mmol) of ter-butyl 2-cyano-6-azaspiro[3.4]octane-6-carboxylate, (isomer 1b), described in Example 8 (step 8.1.) and a catalytic amount of Raney nickel, 0.22 g of product is obtained in the form of a yellow oil, which is used without further purification in the following step.
출처 및 근거
- ORD 기록
- ord-9034527d6ca24057bd172657fac08b9b
- 출처 데이터셋
- uspto-grants-2014_11
- 특허 번호
- US08889702B2
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