4-Fluoro-2-nitrophenol → 2-Amino-4-fluorophenol

HRID 337329

반응식

HRID 337329 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([N+:9]([O-])=O)[CH:3]=1>C(O)C.[Pd]>[NH2:9][C:4]1[CH:3]=[C:2]([F:1])[CH:7]=[CH:6][C:5]=1[OH:8]

참가 물질

4

반응물 1

HCID 1362364-Fluoro-2-nitrophenol

생성물 1

HCID 27359172-Amino-4-fluorophenol수율 86.9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

300 mg of 4-fluoro-2-nitrophenol was dissolved in 3 ml of ethanol, and 120 mg of 10% palladium/carbon was added and stirred under hydrogen atmosphere at room temperature for 1 hour. After the insoluble matter was filtered off, the filtrate was distilled off under reduced pressure to yield 211 mg of the title compound.

후처리

  1. filtrationAfter the insoluble matter was filtered off
  2. distillationthe filtrate was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-3bdbe08535b049f4b504bdb13705ee74
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889727B2

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