Hydrochloric Acid → Indeno(1,2-b)indole

HRID 33733

반응식

HRID 33733 반응식
[C:1]1(=O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.Cl.[C:12]1(C)[CH:17]=[CH:16][C:15]([NH:18]N)=[CH:14][CH:13]=1.Cl>CCO>[CH:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:4]=1[CH:3]=[C:2]1[C:16]3[CH:17]=[CH:12][CH:13]=[CH:14][C:15]=3[N:18]=[C:1]12

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 67351-IndanoneHCID 125044-Methylphenylhydrazine monohydrochloride

생성물 1

HCID 12963293Indeno(1,2-b)indole

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

1-Indanone (30.6 g, 232 mmol), p-tolylhydrazine hydrochloride (37.0 g, 233 mmol) in EtOH (350 mL), and aqueous HCl (12 N, 18 mL) are mixed and the mixture is heated to reflux for 90 min. The mixture is cooled and filtered, and the solid is washed with EtOH (600 mL) and then by 20% aqueous EtOH (400 mL), and finally by hexane (200 mL). The off-white solid is dried under vacuum (36.5 g, 72%).

후처리

  1. temperaturethe mixture is heated
  2. temperatureto reflux for 90 min
  3. temperatureThe mixture is cooled
  4. filtrationfiltered
  5. washthe solid is washed with EtOH (600 mL)
  6. customThe off-white solid is dried under vacuum (36.5 g, 72%)

출처 및 근거

ORD 기록
ord-291cef9a942f450aa2dbd74cde24d56e
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429635B2

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