Water → 1-(2-Methoxyphenyl)-3,4,5-trimethyl-1H-pyrazole

HRID 337333

반응식

HRID 337333 반응식
Cl.[CH3:2][O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][NH2:11].[CH3:12][CH:13]([C:17](=O)[CH3:18])[C:14](=O)[CH3:15].O.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[CH3:2][O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]1[C:17]([CH3:18])=[C:13]([CH3:12])[C:14]([CH3:15])=[N:11]1

참가 물질

6

반응물 4

HCID 962WaterHCID 10340Sodium CarbonateHCID 699493-Methyl-2,4-pentanedioneHCID 28494452-Methoxyphenylhydrazine Hydrochloride

생성물 1

HCID 552194401-(2-Methoxyphenyl)-3,4,5-trimethyl-1H-pyrazole

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

200 mg of 2-methoxyphenyl hydrazine hydrochloride was dissolved in 4 ml of ethanol, and 134 μl of 3-methyl-2,4-pentanedione was added and heated at reflux for 3 hours. To the reaction mixture was added 50 ml of water, neutralized with a saturated aqueous solution of sodium carbonate, and extracted with 60 ml of ethyl acetate. After the organic layer was dried over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure to yield 209.8 mg of the title compound.

후처리

  1. temperatureheated
  2. temperatureat reflux for 3 hours
  3. extractionextracted with 60 ml of ethyl acetate
  4. dry with materialAfter the organic layer was dried over anhydrous magnesium sulfate
  5. distillationthe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-6c70bd91c2274e9ba033fb8f22b7f8e0
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889727B2

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