Water → HCID 178497602, 화합물

HRID 337378

반응식

HRID 337378 반응식
[C:1]([C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][CH:4]=1)#[N:2].Cl.C(N(CC)CC)C.[N-:21]=[N+:22]=[N-:23].[Na+].O>C1(C)C=CC=CC=1>[NH:21]1[C:1]([C:3]2[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][CH:4]=2)=[N:2][N:23]=[N:22]1

참가 물질

6

반응물 4

HCID 962WaterHCID 11130Triethylamine hydrochlorideHCID 33557Sodium AzideHCID 70791Methyl 4-cyanobenzoate

생성물 1

HCID 178497602HCID 178497602, 화합물수율 96%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

1.16 g (10 mmol) of methyl 4-cyanobenzoate, 2.06 g (15 mmol) of triethylamine hydrochloride and 0.98 g (15 mmol) of sodium azide in toluene (20 ml) was allowed to react at 100° C. for 16 hours, and after cooling to room temperature, water (20 ml) was added, and the reaction solution was allowed to separate. Concentrated hydrochloric acid was added to the aqueous layer, and the precipitated colorless solid was collected by filtration through a Kiriyama funnel and dried under reduced pressure to obtain methyl 4-(1H-tetrazol-5-yl)benzoate (1.96 g, yield 96%).

후처리

  1. customto react at 100° C. for 16 hours
  2. customto separate
  3. additionConcentrated hydrochloric acid was added to the aqueous layer
  4. filtrationthe precipitated colorless solid was collected by filtration through a Kiriyama funnel
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-22dbf1ff3bc84e5ea39efa4f046eef76
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889732B2

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