Benzoyl Peroxide → 2-(Bromomethyl)-1-chloro-4-(2-methoxyethoxy)benzene

HRID 337619노트

반응식

HRID 337619 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:9][CH2:10][O:11][CH3:12])=[CH:4][C:3]=1[CH3:13].C1C(=O)N([Br:21])C(=O)C1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:21][CH2:13][C:3]1[CH:4]=[C:5]([O:8][CH2:9][CH2:10][O:11][CH3:12])[CH:6]=[CH:7][C:2]=1[Cl:1]

참가 물질

5

반응물 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 22467254HCID 22467254, 화합물

생성물 1

HCID 591775552-(Bromomethyl)-1-chloro-4-(2-methoxyethoxy)benzene

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

A mixture of 1-chloro-4-(2-methoxyethoxy)-2-methylbenzene (1 eq.) from the previous step, NBS (1.1 eq.) and benzoyl peroxide (0.05 eq.) in CCl4 (0.2 M) was refluxed for 2 h. The volatiles were then removed in vacuo and the resulting residue was suspended in hexanes. The insolubles were removed via filtration and washed further with hexanes. The filtrate was concentrated in vacuo to afford the title compound as a colorless oil.

후처리

  1. temperaturewas refluxed for 2 h
  2. customThe volatiles were then removed in vacuo
  3. customThe insolubles were removed via filtration
  4. washwashed further with hexanes
  5. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-34047ed8e1f54db7a6d2fbe6d7aa3373
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889714B2

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