Sodium borohydride → Methyl 3-bromo-5-(hydroxymethyl)-4-methylbenzoate

HRID 337658노트

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HRID 337658 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([CH:13]=[O:14])[C:11]=1[CH3:12])[C:5]([O:7][CH3:8])=[O:6].[BH4-].[Na+]>CO>[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([CH2:13][OH:14])[C:11]=1[CH3:12])[C:5]([O:7][CH3:8])=[O:6]

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 86651684Methyl 3-bromo-5-formyl-4-methylbenzoate

생성물 1

HCID 66896191Methyl 3-bromo-5-(hydroxymethyl)-4-methylbenzoate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a methanol (0.1 M) solution of methyl 3-bromo-5-formyl-4-methylbenzoate (1 eq.) from the previous step was added sodium borohydride (4 eq.) portionwise. The resulting mixture was stirred at RT for 3 h. The reaction was subsequently quenched with cold 10% aq. HCl and extracted with ether. The combined organic extracts were then washed with water and brine, dried over Na2SO4 and filtered. Concentration of the filtrate in vacuo afforded the title compound as a white solid.

후처리

  1. customThe reaction was subsequently quenched with cold 10% aq. HCl
  2. extractionextracted with ether
  3. washThe combined organic extracts were then washed with water and brine
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered

출처 및 근거

ORD 기록
ord-fafbeae335f44fd68172e70daf5e7c8a
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889714B2

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