2-Isopropylquinoline → 2-Isopropyl-5,6,7,8-tetrahydroquinoline

HRID 33776노트

반응식

HRID 33776 반응식
[CH:1]([C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=1)([CH3:3])[CH3:2]>FC(F)(F)C(O)=O.O=[Pt]=O>[CH:1]([C:4]1[CH:13]=[CH:12][C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[N:5]=1)([CH3:3])[CH3:2]

참가 물질

4

반응물 1

HCID 5133892-Isopropylquinoline

생성물 1

HCID 122294212-Isopropyl-5,6,7,8-tetrahydroquinoline

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 6422Trifluoroacetic acid용매

실험 절차

To a 0.23 M solution of 2-isopropylquinoline in trifluoroacetic acid in a Parr flask was added 0.1 equiv of PtO2. The suspension was set up on the Parr apparatus at 44 psi H2 overnight. After removal of the H2, CH2Cl2 was added, and the suspension was filtered through Celite. The solvent was removed under vacuum, and the residue was partitioned between EtOAc and saturated NaHCO3 solution. The organic layer was washed with H2O and brine, and was then dried over anhydrous MgSO4, filtered and evaporated to give the title compound as a tan colored oil.

후처리

  1. customwas set up on the Parr apparatus at 44 psi H2 overnight
  2. customAfter removal of the H2, CH2Cl2
  3. additionwas added
  4. filtrationthe suspension was filtered through Celite
  5. customThe solvent was removed under vacuum
  6. customthe residue was partitioned between EtOAc and saturated NaHCO3 solution
  7. washThe organic layer was washed with H2O and brine
  8. dry with materialwas then dried over anhydrous MgSO4
  9. filtrationfiltered
  10. customevaporated

출처 및 근거

ORD 기록
ord-9011adc8ebb24f91bdbda6a9f1d612e7
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429666B2

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