Sodium hydride → N-(2,4-Dimethoxybenzyl)-2,5-difluoro-4-{[(1S,2R)-2-(1-methyl-1H-imidazol-5-yl)cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzenesulfonamide

반응식

[CH3:1][O:2][C:3]1[CH:28]=[C:27]([O:29][CH3:30])[CH:26]=[CH:25][C:4]=1[CH2:5][N:6]([C:19]1[CH:24]=[CH:23][N:22]=[CH:21][N:20]=1)[S:7]([C:10]1[CH:15]=[C:14]([F:16])[C:13](F)=[CH:12][C:11]=1[F:18])(=[O:9])=[O:8].[CH3:31][N:32]1[C:36]([CH:37]2[CH2:42][CH2:41][CH2:40][CH2:39][CH:38]2[OH:43])=[CH:35][N:34]=[CH:33]1.[H-].[Na+]>CN(C=O)C>[CH3:1][O:2][C:3]1[CH:28]=[C:27]([O:29][CH3:30])[CH:26]=[CH:25][C:4]=1[CH2:5][N:6]([C:19]1[CH:24]=[CH:23][N:22]=[CH:21][N:20]=1)[S:7]([C:10]1[CH:15]=[C:14]([F:16])[C:13]([O:43][C@H:38]2[CH2:39][CH2:40][CH2:41][CH2:42][C@@H:37]2[C:36]2[N:32]([CH3:31])[CH:33]=[N:34][CH:35]=2)=[CH:12][C:11]=1[F:18])(=[O:8])=[O:9]