Pyrazole → 2,2-dimethyl-1-(1-methyl-1H-pyrazol-5-yl)Cyclopentanol
반응식
[NH:1]1[CH:5]=[CH:4][CH:3]=[N:2]1.[CH2:6]([Li])CCC.[CH3:11][C:12]1([CH3:18])[CH2:16][CH2:15][CH2:14][C:13]1=[O:17]>C1COCC1>[CH3:11][C:12]1([CH3:18])[CH2:16][CH2:15][CH2:14][C:13]1([C:3]1[N:2]([CH3:6])[N:1]=[CH:5][CH:4]=1)[OH:17]참가 물질
5
실험 절차
The reaction and aftertreatment were conducted in the same manner as in Example 8a by using pyrazole (3.70 g, 45.1 mmol), n-butyl lithium (2.69 M solution in hexane; 17 mL, 45.7 mmol), 2,2-dimethylcyclopentanone (5.00 g, 44.6 mmol) and THF (100 mL), to yield the title compound (630 mg, 7.3%) as a colorless solid.
후처리
- customThe reaction and aftertreatment
출처 및 근거
- ORD 기록
- ord-fd8cd709a1254c549eb6dcc43a7ba25a
- 출처 데이터셋
- uspto-grants-2014_11
- 특허 번호
- US08889741B2
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