Pyrazole → HCID 79863038, 화합물

HRID 337877

반응식

HRID 337877 반응식
[NH:1]1[CH:5]=[CH:4][CH:3]=[N:2]1.[CH2:6]([Li])CCC.[CH3:11][C:12]1([CH3:18])[CH2:16][CH2:15][CH2:14][C:13]1=[O:17]>C1COCC1>[CH3:11][C:12]1([CH3:18])[CH2:16][CH2:15][CH2:14][C:13]1([C:3]1[N:2]([CH3:6])[N:1]=[CH:5][CH:4]=1)[OH:17]

참가 물질

5

반응물 3

HCID 1048PyrazoleHCID 1382862,2-DimethylcyclopentanoneHCID 178418339Butyllithium

생성물 1

HCID 79863038HCID 79863038, 화합물수율 7.3%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The reaction and aftertreatment were conducted in the same manner as in Example 8a by using pyrazole (3.70 g, 45.1 mmol), n-butyl lithium (2.69 M solution in hexane; 17 mL, 45.7 mmol), 2,2-dimethylcyclopentanone (5.00 g, 44.6 mmol) and THF (100 mL), to yield the title compound (630 mg, 7.3%) as a colorless solid.

후처리

  1. customThe reaction and aftertreatment

출처 및 근거

ORD 기록
ord-fd8cd709a1254c549eb6dcc43a7ba25a
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889741B2

연결된 노트

불러오는 중…