Hydrochloric Acid → 2-(4-Bromophenyl)pyrrolidine hydrochloride

HRID 338426

반응식

HRID 338426 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:12][CH2:11][CH2:10][N:9]2C(OC(C)(C)C)=O)=[CH:4][CH:3]=1.[ClH:20]>CO>[ClH:20].[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[CH2:12][CH2:11][CH2:10][NH:9]2)=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 53407516tert-Butyl 2-(4-bromophenyl)pyrrolidine-1-carboxylate

생성물 1

HCID 534075152-(4-Bromophenyl)pyrrolidine hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

The suspension of tert-butyl 2-(4-bromophenyl)pyrrolidine-1-carboxylate (1.2 g, 3.7 mmol) in anhydrous methanol (10 mL) was added hydrogen chloride in methanol (20 mL, 4.0M in MeOH) under nitrogen. The reaction was stirred at room temperature for 1.5 hours. The mixture was concentrated to afford the title compound (0.99 g, quantitative yield) which was used without purification in the next step.

후처리

  1. concentrationThe mixture was concentrated

출처 및 근거

ORD 기록
ord-fee60a7d31904186b2bff237eb169f36
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889730B2

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