(1-(4-Bromophenyl)cyclobutyl)methanol → 4,6-difluoro-5-(4-(1-(hydroxymethyl)cyclobutyl)phenyl)-1H-indole-3-carbaldehyde

HRID 338515

반응식

HRID 338515 반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH2:12][OH:13])[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.Br[C:15]1[C:16]([F:27])=[C:17]2[C:21](=[CH:22][C:23]=1[F:24])[NH:20][CH:19]=[C:18]2[CH:25]=[O:26]>>[F:27][C:16]1[C:15]([C:2]2[CH:7]=[CH:6][C:5]([C:8]3([CH2:12][OH:13])[CH2:11][CH2:10][CH2:9]3)=[CH:4][CH:3]=2)=[C:23]([F:24])[CH:22]=[C:21]2[C:17]=1[C:18]([CH:25]=[O:26])=[CH:19][NH:20]2

참가 물질

3

반응물 2

HCID 58538689(1-(4-Bromophenyl)cyclobutyl)methanolHCID 866985785-Bromo-4,6-difluoro-1H-indole-3-carbaldehyde

생성물 1

HCID 866988454,6-difluoro-5-(4-(1-(hydroxymethyl)cyclobutyl)phenyl)-1H-indole-3-carbaldehyde

실험 절차

[1-(4-bromophenyl)cyclobutyl]methanol, prepared as described in Example 72 (steps 1 and 2), is treated with 5-bromo-4,6-difluoro-1H-indole-3-carbaldehyde, prepared as described in Example 6 (steps 1-4), in a manner similar as described in Example 6 step 5 to provide the title compound.

후처리

  1. customprepared

출처 및 근거

ORD 기록
ord-11765295e5174708a5b780ec3251fd15
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889730B2

연결된 노트

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