3-(3,4,5-Trimethoxyphenyl)acrylic acid → HCID 67078913, 화합물

HRID 338619

반응식

HRID 338619 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]=[C:12]([O:16][CH3:17])[C:13]=1[O:14][CH3:15])[CH:6]=[CH:7][C:8]([OH:10])=O.S(Cl)(Cl)=O.[NH2:22][CH:23]([C:31]1[CH:39]=[CH:38][C:34]([C:35]([OH:37])=[O:36])=[CH:33][CH:32]=1)CC1C=CC=CC=1.[OH-].[Na+]>ClCCl>[CH3:17][O:16][C:12]1[CH:11]=[C:5]([CH:4]=[C:3]([O:2][CH3:1])[C:13]=1[O:14][CH3:15])[CH:6]=[CH:7][C:8]([NH:22][CH2:23][C:31]1[CH:32]=[CH:33][C:34]([C:35]([OH:37])=[O:36])=[CH:38][CH:39]=1)=[O:10]

참가 물질

6

반응물 4

HCID 70213-(3,4,5-Trimethoxyphenyl)acrylic acidHCID 14798Sodium HydroxideHCID 24386Thionyl ChlorideHCID 103994424-(1-Amino-2-phenylethyl)benzoic acid

생성물 1

HCID 67078913HCID 67078913, 화합물수율 113.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3,4,5-trimethoxycinnamic acid (2.38 g, 10 mmol), thionylchloride (4.72 g, 40 mmol), dichloromethane (10 ml), 4-(1-amino-2-phenylethyl)benzoic acid (2.41 g, 10 mmol), and 10 ml of 1 mol/L sodium hydroxide are used according to the method for the production of compound III in Method one to obtain 4.20 g of 4-[(3,4,5-trimethoxycinnamoyl)aminomethyl]benzoic acid (intermediate M-42) as a white solid, with a yield of 91.2%.

출처 및 근거

ORD 기록
ord-0f086c75a7d24abf9c1e1bc1a79427cb
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889876B2

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