4-(Quinolin-2-ylmethoxy)aniline → 4-(Quinolin-2-ylmethoxy)phenylhydrazine

HRID 33885

반응식

HRID 33885 반응식
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([NH2:19])=[CH:15][CH:14]=1.[N:20]([O-])=O.[Na+].[Sn]>Cl>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:14]=[CH:15][C:16]([NH:19][NH2:20])=[CH:17][CH:18]=1

참가 물질

5

반응물 3

HCID 27475694-(Quinolin-2-ylmethoxy)anilineHCID 5352426Tin atomHCID 23668193Sodium Nitrite

생성물 1

HCID 152250684-(Quinolin-2-ylmethoxy)phenylhydrazine

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매2회

실험 절차

To a suspension of 4-(Quinolin-2-ylmethoxy)-phenylamine (1.73 g) in 30 mL of concentrated HCl at 0° C. was added sodium nitrite (531 mg). After 3 h, tin chlrodie (3.95 g) was dissolved in 20 mL of concentrated HCl and added slowly dropwise and the reaction mixture stirred at ambient temperature for 18 h. The reaction mixture was filtered and the solid dried to provide the title compound as the HCL salt (3.94 g). MS: (M+H m/z=266.3).

후처리

  1. additionadded slowly dropwise
  2. filtrationThe reaction mixture was filtered
  3. customthe solid dried

출처 및 근거

ORD 기록
ord-95238443306142f79127fd0dcfbeea54
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429665B2

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