Methane → 2-(Methoxymethyl)aniline

HRID 339005노트

반응식

HRID 339005 반응식
[CH3:1][O:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N+:10]([O-])=O.[H][H].C>CO.O=[Pt]=O>[CH3:1][O:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH2:10]

참가 물질

6

반응물 3

HCID 297MethaneHCID 126166891-(Methoxymethyl)-2-nitrobenzeneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 123343062-(Methoxymethyl)aniline수율 97%

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 887Methanol용매

실험 절차

A solution of 1-(methoxymethyl)-2-nitrobenzene (4.30 g, 25.7 mmol) and PtO2 (0.29 g, 1.29 mmol) in MeOH (30 mL) was charged with 1 atmosphere hydrogen and stirred at ambient temperature for 1 hour. Charcoal (5 g) was added and the reaction mixture was stirred for 10 minutes. The solid was removed by filtration and washed with methanol. The filtrate was concentrated under reduced pressure to give 2-(methoxymethyl)aniline (3.42 g, 96.9%) as a solid.

후처리

  1. stirringthe reaction mixture was stirred for 10 minutes
  2. customThe solid was removed by filtration
  3. washwashed with methanol
  4. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-f7367e47b3244552ae1321ad6a778546
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889704B2

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