Cycloheptylamine → N-cycloheptyl-2,3,5,6-tetrafluoro-4-methylbenzamide

반응식

[CH:1]1([NH2:8])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[F:9][C:10]1[C:15]([F:16])=[C:14]([C:17](O)=[O:18])[C:13]([F:20])=[C:12]([F:21])[C:11]=1[CH3:22]>>[CH:1]1([NH:8][C:17](=[O:18])[C:14]2[C:13]([F:20])=[C:12]([F:21])[C:11]([CH3:22])=[C:10]([F:9])[C:15]=2[F:16])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

반응물 2

HCID 2899Cycloheptylamine

HCID 69548p-Toluic acid, 2,3,5,6-tetrafluoro-

생성물 1

HCID 57527795N-cycloheptyl-2,3,5,6-tetrafluoro-4-methylbenzamide

실험 절차

Prepared in a similar manner to Example 162 using cycloheptylamine and 2,3,5,6-tetrafluoro-p-toluic acid (94%). 1H NMR (CDCl3) δ 1.53 (m, 6H), 1.57 (m, 4H), 2.03 (m, 2H) 2.28 (m, 3H), 4.17 (m, 1H), 5.85 (bs, 1H). MS (304.1, M+H) m. p. 164-165° C.

출처 및 근거

ORD 기록: ord-58c2686c0d494547812b9bd9d5356594
출처 데이터셋: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08895050B2

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