Malonic Acid → 3-Amino-3-(2,5-difluorophenyl)propanoic acid
반응식
[F:1][C:2]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:3]=1[CH:4]=O.[C:11]([OH:17])(=[O:16])[CH2:12]C(O)=O.C([O-])(=O)C.[NH4+:22]>C(O)C>[NH2:22][CH:4]([C:3]1[CH:6]=[C:7]([F:10])[CH:8]=[CH:9][C:2]=1[F:1])[CH2:12][C:11]([OH:17])=[O:16]참가 물질
5
실험 절차
A solution of 2,5-difluorobenzaldehyde (5 g), malonic acid (3.66 g) and ammonium acetate (5.42 g) in ethanol (50 ml) was heated under reflux for six hours. The mixture was cooled and left to stand overnight. The crystals formed were filtered off and washed with ethanol (5 ml).
후처리
- temperatureunder reflux for six hours
- temperatureThe mixture was cooled
- waitleft
- customThe crystals formed
- filtrationwere filtered off
- washwashed with ethanol (5 ml)
출처 및 근거
- ORD 기록
- ord-6689b046683d40b2bf586448f5338a30
- 출처 데이터셋
- uspto-grants-2014_11
- 특허 번호
- US08895547B2
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