Monobasic potassium phosphate → HCID 7091053, 화합물
반응식
C([O:3][C:4](=[O:16])[CH2:5][CH:6]([NH2:15])[C:7]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:8]=1[F:14])C.P([O-])(O)(O)=O.[K+]>O>[NH2:15][C@H:6]([C:7]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:8]=1[F:14])[CH2:5][C:4]([OH:16])=[O:3]참가 물질
4
실험 절차
3-Amino-3-(2,5-difluorophenyl)propionic acid ethyl ester (3 g) was emulsified in water (pH=9.2) and admixed with potassium dihydrogenphosphate (5 mg) (pH=8.5). After addition of Amano Lipase PS (150 mg), the mixture was stirred overnight. The pH remains at 7.5. The mixture was then admixed with water (30 ml) and filtered through kieselguhr and washed several more times with water. The aqueous phase was then extracted with dichloromethane (3×30 ml), and the organic phase was dried (Na2SO4) and concentrated. This gave the product (1.3 g) with an ee=90% by HPLC.
후처리
- additionAfter addition of Amano Lipase PS (150 mg)
- filtrationfiltered through kieselguhr
- washwashed several more times with water
- extractionThe aqueous phase was then extracted with dichloromethane (3×30 ml)
- dry with materialthe organic phase was dried (Na2SO4)
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-50215cbfa0844d518cd67d540ea07104
- 출처 데이터셋
- uspto-grants-2014_11
- 특허 번호
- US08895547B2
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