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Methanol → (2S)-2-[(tert-butoxycarbonyl)amino]-3-(2-methoxypyridin-4-yl)propanoic acid

HRID 339954
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HRID 339954 반응식
[C:1]([O:5][C:6]([NH:8][C@@H:9]([CH2:14][C:15]1[CH:20]=[CH:19][N:18]=[C:17]([O:21][CH3:22])[CH:16]=1)[C:10]([O:12]C)=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].CO.[OH-].[Li+].O1CCOCC1.Cl>O>[C:1]([O:5][C:6]([NH:8][C@@H:9]([CH2:14][C:15]1[CH:20]=[CH:19][N:18]=[C:17]([O:21][CH3:22])[CH:16]=1)[C:10]([OH:12])=[O:11])=[O:7])([CH3:3])([CH3:4])[CH3:2]
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참가 물질

6

반응물 4

HCID 887MethanolHCID 3939Lithium HydroxideHCID 204431481,4-Dioxane hydrochlorideHCID 86681449Methyl (2S)-2-[(tert-butoxycarbonyl)amino]-3-(2-methoxypyridin-4-yl)propanoate

생성물 1

HCID 86681448(2S)-2-[(tert-butoxycarbonyl)amino]-3-(2-methoxypyridin-4-yl)propanoic acid

시약·촉매·용매 1

HCID 962
Water
용매

실험 절차

Methyl (2S)-2-[(tert-butoxycarbonyl)amino]-3-(2-methoxypyridin-4-yl)propanoate (1.42 g, 4.58 mmol) was mixed with methanol (10.0 mL) and a solution of lithium hydroxide (0.66 g, 14 mmol) in water (5.0 mL). The mixture was stirred at rt for 1 h. The mixture was then acidified with 4 N HCl dioxane solution and condensed under vacuum directly to give the white solid mixture, which was used directly in the next step. LC-MS found: 297.1 (M+H)+.

후처리

  1. customto give the white solid mixture, which

출처 및 근거

ORD 기록
ord-978dd80c7cf44bd48c3bbd52e5d74859
출처 데이터셋
uspto-grants-2014_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08895571B2

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