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Hydrochloric Acid → (2S)-2-amino-3-(2-methoxypyridin-4-yl)propan-1-ol

HRID 339956
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HRID 339956 반응식
[OH:1][CH2:2][C@@H:3]([NH:13]C(=O)OC(C)(C)C)[CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]([O:11][CH3:12])[CH:6]=1.CO.Cl>O1CCOCC1>[NH2:13][C@@H:3]([CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]([O:11][CH3:12])[CH:6]=1)[CH2:2][OH:1]
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참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 86681450tert-butyl {(1S)-2-hydroxy-1-[(2-methoxypyridin-4-yl)methyl]ethyl}carbamate

생성물 1

HCID 86681451(2S)-2-amino-3-(2-methoxypyridin-4-yl)propan-1-ol

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To a vial was added tert-butyl {(1S)-2-hydroxy-1-[(2-methoxypyridin-4-yl)methyl]ethyl}carbamate (0.50 g, 1.8 mmol) and methanol (2.0 mL) and 4.0 M hydrogen chloride in dioxane (5.0 mL, 20. mmol). The reaction was stirred at room temperature overnight. Direct evaporation under reduced pressure afforded the final compound. LC-MS found: 183.0 (M+H)+.

후처리

  1. customDirect evaporation under reduced pressure

출처 및 근거

ORD 기록
ord-bf2fac308f5e43a48dd05446ff79197b
출처 데이터셋
uspto-grants-2014_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08895571B2

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