Water → 2-((E)-2-(3-fluorophenyl)ethenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

HRID 34031

반응식

HRID 34031 반응식
[CH3:1][C:2]1([CH3:9])[C:6]([CH3:8])([CH3:7])[O:5][BH:4][O:3]1.[F:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=1)[CH:14]=[CH2:15].O>C1(C)C=CC=CC=1.C1CC=CCCC=C1.C1CC=CCCC=C1.[Cl-].[Cl-].[Rh].[Rh]>[F:10][C:11]1[CH:12]=[C:13](/[CH:14]=[CH:15]/[B:4]2[O:5][C:6]([CH3:8])([CH3:7])[C:2]([CH3:9])([CH3:1])[O:3]2)[CH:16]=[CH:17][CH:18]=1

참가 물질

6

반응물 3

HCID 962WaterHCID 676913-FluorostyreneHCID 27347684,4,5,5-Tetramethyl[1,3,2]dioxaborolane

생성물 1

HCID 597970362-((E)-2-(3-fluorophenyl)ethenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

시약·촉매·용매 2

HCID 6436379Rhodium, di-mu-chlorobis((1,2,5,6-eta)-1,5-cyclooctadiene)di-촉매HCID 1140Toluene용매

실험 절차

To a solution of 11 mg of chloro(1,5-cyclooctadiene)-rhodium(I) dimer and 0.61 mL of 4,4,5,5-tetramethyl-[1,3,2]dioxaborolane in 15 mL toluene was added dropwise 1.0 mL of 3-fluorostyrene, and stirred at room temperature for 4 hours. The reaction solution was added with water, and dried over anhydrous magnesium sulfate. The solvent was evaporated, and the resultant crude product was purified and separated by silica gel column chromatography (diethyl ether:n-hexane=1:19), to afford 311 mg of the title compound as a pale yellow oil.

후처리

  1. dry with materialdried over anhydrous magnesium sulfate
  2. customThe solvent was evaporated
  3. customthe resultant crude product was purified
  4. customseparated by silica gel column chromatography (diethyl ether:n-hexane=1:19)

출처 및 근거

ORD 기록
ord-19f3cf7530ff411ea7fc46d3b23c22cf
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429609B2

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