Dimethylformamide dimethyl acetal → 1-(5-Bromopyridin-3-yl)-3-(dimethylamino)prop-2-ene-1-one

반응식

CO[CH:3](OC)[N:4]([CH3:6])[CH3:5].[Br:9][C:10]1[CH:11]=[C:12]([C:16](=[O:18])[CH3:17])[CH:13]=[N:14][CH:15]=1>>[Br:9][C:10]1[CH:11]=[C:12]([C:16](=[O:18])[CH:17]=[CH:3][N:4]([CH3:5])[CH3:6])[CH:13]=[N:14][CH:15]=1

참가 물질

반응물 2

HCID 78373Dimethylformamide dimethyl acetal

HCID 8204233-Acetyl-5-bromopyridine

생성물 1

HCID 670572791-(5-Bromopyridin-3-yl)-3-(dimethylamino)prop-2-ene-1-one

반응 조건

온도: 100 °C

실험 절차

An N,N-dimethylformamide dimethylacetal (2 ml) solution containing 1-(5-bromopyridin-3-yl)ethanone (100 mg) (WO2009/87224 A1) was stirred at 100° C. for 5 hours. The solvent was distilled away under reduced pressure, and a yellow solid of 1-(5-bromopyridin-3-yl)-3-(dimethylamino)prop-2-ene-1-one was thus obtained.

후처리

distillationThe solvent was distilled away under reduced pressure

출처 및 근거

ORD 기록: ord-9ea3052c2c8641589f76c41843130f54
출처 데이터셋: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08895585B2

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