Ethanone, 1-(1H-pyrazolo[4,3-c]pyridin-1-yl)- → 1H-Pyrazolo[4,3-c]pyridine

HRID 34082노트

반응식

HRID 34082 반응식
[N:1]1(C(=O)C)[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[N:2]1>C(O)C.[OH-].[Na+]>[NH:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[N:2]1

참가 물질

4

반응물 1

HCID 23070130Ethanone, 1-(1H-pyrazolo[4,3-c]pyridin-1-yl)-

생성물 1

HCID 199305001H-Pyrazolo[4,3-c]pyridine수율 81.5%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 14798Sodium Hydroxide용매

실험 절차

To a solution of 6.44 g of 1-pyrazolo[4,3-c]pyridin-1-yl-ethanone in 120 mL of ethanol, 10 mL of 5N sodium hydroxide aqueous solution was added at room temperature and stirred at this temperature for 30 minutes. After neutralization with 5N hydrochloric acid, the solvent was evaporated, the residue was washed with ethyl acetate, and the solvent of filtrate was evaporated, to afford 3.88 g of the title compound as pale yellow crystals.

후처리

  1. customAfter neutralization with 5N hydrochloric acid, the solvent was evaporated
  2. washthe residue was washed with ethyl acetate
  3. customthe solvent of filtrate was evaporated

출처 및 근거

ORD 기록
ord-bc9584153d024b7d907f9748370ecf08
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429609B2

반응 노트

불러오는 중…