Hydrochloric Acid → HCID 178418440, 화합물

HRID 3410노트

반응식

HRID 3410 반응식
Cl.S(OS([O-])(=O)=O)([O-])(=O)=[O:3].[NH2:11][C:12]1[N:13]=[CH:14][C:15]2[CH:21]=[C:20]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:19](N)=[N:18][C:16]=2[N:17]=1>O>[NH2:11][C:12]1[N:13]=[CH:14][C:15]2[CH:21]=[C:20]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:19]([OH:3])=[N:18][C:16]=2[N:17]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 177717DisulfateHCID 108474752,7-Diamino-6-phenylpyrido[2,3-d]pyrimidine

생성물 1

HCID 178418440HCID 178418440, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of 2 L of concentrated HCl and 1 L of water is added 300 g of the disulfate salt of 2,7-diamino-6-phenylpyrido[2,3-d]pyrimidine and the resulting mixture refluxed with stirring overnight. The reaction mixture is cooled in an ice bath, filtered, and the insoluble product washed with water, followed by ethanol to give 149 g of the title compound 2-amino-6-phenyl-pyrido[2,3-d]pyrimidin-7-ol, mp 390°-395° C. (darkens slowly above 350° C.).

후처리

  1. temperaturethe resulting mixture refluxed
  2. temperatureThe reaction mixture is cooled in an ice bath
  3. filtrationfiltered
  4. washthe insoluble product washed with water

출처 및 근거

ORD 기록
ord-8ab3a8e6f55f47d8b365c3064b07de67
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05733913

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