Benzoyl Peroxide → 1-(Bromomethyl)-2-fluoro-4-iodobenzene

HRID 341038

반응식

HRID 341038 반응식
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[CH3:9].[Br:10]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:10][CH2:9][C:3]1[CH:4]=[CH:5][C:6]([I:8])=[CH:7][C:2]=1[F:1]

참가 물질

5

반응물 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 1234922-Fluoro-4-iodotoluene

생성물 1

HCID 222404061-(Bromomethyl)-2-fluoro-4-iodobenzene

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

2-Fluoro-4-iodo-1-methylbenzene (2.0 g, 8.6 mmol) was dissovled in carbon tetrachloride (10 mL), treated with N-bromosuccinimide (1.5 g, 8.6 mmol, 1 equiv) and benzoyl peroxide (9.0 mg, 0.004 equiv) and placed into an oil bath preheated to 80° C. for 3 hours. The mixture was cooled to ambient temperature, filtered and the filtrate was concentrated in vacuo, providing the titled compound.

후처리

  1. customplaced into an oil bath
  2. filtrationfiltered
  3. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-6317748c3b054fe5b1ecf65ca3bcedde
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08895580B2

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