Potassium Carbonate → HCID 178515185, 화합물

Ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate (3.8 g, 17 mmol) was dissolved in phosphorus oxychloride (25 mL, 0.26 mol, 15 equiv) and stirred at ambient temperature for 14 hours. The mixture was concentrated in vacuo and the residue was concentrated from toluene (3×25 mL). The resulting residue was dissolved in 1,2-dimethoxyethane (60 mL) and degassed N,N-dimethylformamide (10 mL) and treated with 2-fluorophenylhydrazine (4.4 g, 35 mmol, 2 equiv) and potassium carbonate (12 g, 87 mmol, 5 equiv). The mixture was placed into a preheated oil bath at 80° C. for 14 hours. The mixture was cooled to ambient temperature, diluted with water (100 mL) and ethyl acetate (100 mL) and filtered. The solid was collected and dried in vacuo, providing the titled compound as a yellow solid.

1. concentrationThe mixture was concentrated in vacuo
2. concentrationthe residue was concentrated from toluene (3×25 mL)
3. dissolutionThe resulting residue was dissolved in 1,2-dimethoxyethane (60 mL)
4. customdegassed N,N-dimethylformamide (10 mL)
5. waitThe mixture was placed into a preheated oil bath at 80° C. for 14 hours
6. temperatureThe mixture was cooled to ambient temperature
7. filtrationfiltered
8. customThe solid was collected
9. customdried in vacuo

ORD 기록

ord-2fb7e142bd944a25baabe0eeeb5d94ca

출처 데이터셋

uspto-grants-2014_11

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08895580B2