Sodium Carbonate → 1-BOC-4-(4-bromophenoxy)piperidine

HRID 341168

반응식

HRID 341168 반응식
[Br:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][CH:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)=[CH:4][CH:3]=1.C([O-])([O-])=O.[Na+].[Na+].[O:21](C(OC(C)(C)C)=O)[C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=O>O1CCOCC1.O>[C:25]([O:24][C:22]([N:10]1[CH2:9][CH2:8][CH:7]([O:6][C:5]2[CH:13]=[CH:14][C:2]([Br:1])=[CH:3][CH:4]=2)[CH2:12][CH2:11]1)=[O:21])([CH3:28])([CH3:27])[CH3:26]

참가 물질

6

반응물 3

HCID 10340Sodium CarbonateHCID 90495Di-tert-butyl dicarbonateHCID 126455664-(4-Bromophenoxy)piperidine

생성물 1

HCID 467390061-BOC-4-(4-bromophenoxy)piperidine수율 86.4%

시약·촉매·용매 2

HCID 962Water용매HCID 312751,4-Dioxane용매

실험 절차

To a solution of 4-(4-Bromo-phenoxy)-piperidine (1 g, 3.9 mmol) in dioxane (20 ml), water (20 ml) added Na2CO3 (1.6 g, 18.9 mmol) and (BOC)2O (1.3 g, 5.9 mmol). Reaction stirred at ambient for 48 hours, solvent was removed under reduced pressure and residue partitioned between EtOAc and water the layers were separated. The organic layer was washed with brine, dried (MgSO4), and concentrated under reduced pressure to give (1.2 g) of product.

후처리

  1. customReaction
  2. customsolvent was removed under reduced pressure and residue
  3. custompartitioned between EtOAc and water the layers
  4. customwere separated
  5. washThe organic layer was washed with brine
  6. dry with materialdried (MgSO4)
  7. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-c093a24d27e94e44a89572729fb84f14
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08895745B2

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