Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Amino-3-(morpholin-4-yl)propan-2-ol → 3-[(E)-2-(4-fluorophenyl)ethenyl]-N-(2-hydroxy-3-morpholin-4-ylpropyl)-4-methoxy-1H-indazole-5-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Amino-3-(morpholin-4-yl)propan-2-ol | HCID 2832231 | — |
| 반응물 | 3-[(E)-2-(4-fluorophenyl)-vinyl]-4-methoxy-1H-indazole-5-carboxylic acid | HCID 59797243 | — |
| 생성물 | 3-[(E)-2-(4-fluorophenyl)ethenyl]-N-(2-hydroxy-3-morpholin-4-ylpropyl)-4-methoxy-1H-indazole-5-carboxamide | HCID 60034861 | 45.4% |
반응 단계
100 mg of 3-[(E)-2-(4-fluorophenyl)-vinyl]-4-methoxy-1H-indazole-5-carboxylic acid obtained by Example 234 and 130 mg of 1-amino-3-(morpholine-4-yl)propane-2-ol were condensed in the similar method as described in Example 44, to afford 66 mg of the title compound as colorless needle crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07429609B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-cdbb4289407b462dab29ea96153df71a |
| 출처 메모 | uspto-grants-2008_09 |