Morpholine → HCID 14568660, 화합물

HRID 34118

반응식

HRID 34118 반응식
[C:1]([O:4][CH2:5][C:6]1[O:10][C:9]([CH:11]=O)=[CH:8][CH:7]=1)(=[O:3])[CH3:2].[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>ClCCCl.ClCCl>[N:13]1([CH2:11][C:9]2[O:10][C:6]([CH2:5][O:4][C:1](=[O:3])[CH3:2])=[CH:7][CH:8]=2)[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1

참가 물질

6

반응물 3

HCID 8083MorpholineHCID 663495-Acetoxymethyl-2-furaldehydeHCID 5049666Sodium triacetoxyborohydride

생성물 1

HCID 14568660HCID 14568660, 화합물

시약·촉매·용매 2

HCID 111,2-Dichloroethane용매HCID 6344Dichloromethane용매

실험 절차

Under nitrogen atmosphere, to a solution of 2.0 g of 5-acetoxymethyl-2-furanaldehyde and 1.1 mL of morpholine in 35 mL of 1,2-dichloroethane was added 4.0 g of sodium triacetoxy borohydride at room temperature, and stirred at this temperature for 3 hours. The reaction solution was diluted with dichloromethane, washed successively with saturated aqueous sodium hydrogen carbonate and saturated brine, and then dried over anhydrous magnesium sulfate. The solvent was evaporated, and the residue was purified and separated by silica gel column chromatography, to afford 2.3 g of the title compound as a colorless oil.

후처리

  1. washwashed successively with saturated aqueous sodium hydrogen carbonate and saturated brine
  2. dry with materialdried over anhydrous magnesium sulfate
  3. customThe solvent was evaporated
  4. customthe residue was purified
  5. customseparated by silica gel column chromatography

출처 및 근거

ORD 기록
ord-c408746cbab8470790f98487d756d10d
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429609B2

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