1,2-Dichloroethane → 2-Imino-1(1-iodo-vinyl)-1,2-dihydro-pyridine-4-carboxylic acid N'-(2-fluoro-acetyl)-hydrazide

HRID 341220노트

반응식

HRID 341220 반응식
[F:1][CH2:2][C:3]([OH:5])=O.C(Cl)CCl.[I:10][C:11]1[N:15]2[CH:16]=[CH:17][C:18]([C:20]([NH:22][NH2:23])=[O:21])=[CH:19][C:14]2=[N:13][CH:12]=1>C(Cl)Cl.CN(C1C=CN=CC=1)C>[F:1][CH2:2][C:3]([NH:23][NH:22][C:20]([C:18]1[CH:17]=[CH:16][N:15]([C:11]([I:10])=[CH2:12])[C:14](=[NH:13])[CH:19]=1)=[O:21])=[O:5]

참가 물질

6

반응물 3

HCID 111,2-DichloroethaneHCID 5237Fluoroacetic acidHCID 593209453-Iodo-imidazo[1,2-a]pyridine-7-carboxylic acid hydrazide

생성물 1

HCID 866415502-Imino-1(1-iodo-vinyl)-1,2-dihydro-pyridine-4-carboxylic acid N'-(2-fluoro-acetyl)-hydrazide

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6344Dichloromethane용매

실험 절차

To a solution of fluoroacetic acid (52 mg, 0.66 mmol) in CH2Cl2 (5 ml) was added EDC (127 mg, 0.66 mmol) and DMAP (5 mg, catalytic) and the reaction mixture stirred at room temperature for 15 min. 3-Iodo-imidazo[1,2-a]pyridine-7-carboxylic acid hydrazide (prepared as described in Example 329 steps a-c) (100 mg, 0.33 mmol) was added and the reaction mixture stirred at room temperature for 18 h. The reaction mixture was filtered, the precipitate washed with Et2O and dried to afford a crude product which was used directly in the next reaction (101 mg). MS: [M+H]+=363.

후처리

  1. stirringthe reaction mixture stirred at room temperature for 18 h
  2. filtrationThe reaction mixture was filtered
  3. washthe precipitate washed with Et2O
  4. customdried

출처 및 근거

ORD 기록
ord-e6372afe9e3e458389c36007414920ad
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08895745B2

반응 노트

불러오는 중…