Hydrochloric Acid → HCID 59320781, 화합물

HRID 341225노트

반응식

HRID 341225 반응식
C([O:3][C:4](=[O:31])/[CH:5]=[CH:6]/[C:7]1[CH:12]=[CH:11][N:10]2[C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([NH:22][C:23]([NH:25][CH2:26][C:27]([F:30])([F:29])[F:28])=[O:24])[CH:17]=3)=[CH:14][N:15]=[C:9]2[CH:8]=1)C.C([O-])([O-])=O.[Na+].[Na+].Cl>CCO>[F:30][C:27]([F:28])([F:29])[CH2:26][NH:25][C:23](=[O:24])[NH:22][C:18]1[CH:17]=[C:16]([C:13]2[N:10]3[CH:11]=[CH:12][C:7](/[CH:6]=[CH:5]/[C:4]([OH:31])=[O:3])=[CH:8][C:9]3=[N:15][CH:14]=2)[CH:21]=[CH:20][CH:19]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 59321019HCID 59321019, 화합물

생성물 1

HCID 59320781HCID 59320781, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

To a solution of (E)-3-(3-{3-[3-(2,2,2-Trifluoro-ethyl)-ureido]-phenyl}-imidazo[1,2-a]pyridin-7-yl)-acrylic acid ethyl ester (83 mg, 0.19 mmol) in EtOH (10 ml) was added 1M Na2CO3 (4 ml) and the reaction heated to 80° C. for 1.5 h. The reaction was neutralised using 1M HCl and then concentrated. The residue was taken up in hot EtOH, filtered and the solvent removed in vacuo to afford the product. MS: [M+H]+ 405.

후처리

  1. concentrationconcentrated
  2. filtrationfiltered
  3. customthe solvent removed in vacuo
  4. customto afford the product

출처 및 근거

ORD 기록
ord-67b7425560b5433cb5002489e872b1a1
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08895745B2

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