Acetic Anhydride → N-(4-Bromo-5-fluoro-2-methylphenyl)acetamide

HRID 34126노트

반응식

HRID 34126 반응식
C(O[C:5](=[O:7])[CH3:6])(=O)C.[Br:8][C:9]1[C:14]([F:15])=[CH:13][C:12]([NH2:16])=[C:11]([CH3:17])[CH:10]=1>>[Br:8][C:9]1[C:14]([F:15])=[CH:13][C:12]([NH:16][C:5](=[O:7])[CH3:6])=[C:11]([CH3:17])[CH:10]=1

참가 물질

3

반응물 2

HCID 7918Acetic AnhydrideHCID 70180444-Bromo-5-fluoro-2-methylaniline

생성물 1

HCID 23070217N-(4-Bromo-5-fluoro-2-methylphenyl)acetamide

실험 절차

73.6 mL of acetic anhydride was added with 80.0 g of 4-bromo-5-fluoro-2-methylphenylamine at room temperature, and stirred at this temperature for 10 minutes. Excess acetic anhydride was distilled off under reduced pressure, and the precipitated crystals were washed with water, to afford 77.6 g of the title compound as colorless crystal.

후처리

  1. distillationExcess acetic anhydride was distilled off under reduced pressure
  2. washthe precipitated crystals were washed with water

출처 및 근거

ORD 기록
ord-d239774155d24cce85ad6d774c49788d
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429609B2

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