Hydrochloric Acid → HCID 25154341, 화합물

HRID 341279노트

반응식

HRID 341279 반응식
C([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11](=[O:22])[NH:12][C:13]1[S:14][C:15]([S:18]([CH3:21])(=[O:20])=[O:19])=[CH:16][N:17]=1)(=O)C.Cl>C1COCC1>[OH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]([NH:12][C:13]1[S:14][C:15]([S:18]([CH3:21])(=[O:20])=[O:19])=[CH:16][N:17]=1)=[O:22]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 251886012-(Acetyloxy)-N-[5-(methylsulfonyl)-2-thiazolyl]benzamide

생성물 1

HCID 25154341HCID 25154341, 화합물수율 95.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 7 (1.0 g, 2.94 mmol, 1.0 eq) dissolved in THF (20 mL) was added under stirring to 2M HCl (100 mL). The reaction was refluxed for one hour and allowed to cool under stirring over one hour. The product was filtered using a sintered glass funnel, washed with distilled water and THF and dried in high vacuum to afford 834 mg (95%) of 6 as a colorless solid.

후처리

  1. additionwas added
  2. temperatureThe reaction was refluxed for one hour
  3. temperatureto cool
  4. filtrationThe product was filtered
  5. washwashed with distilled water and THF
  6. customdried in high vacuum

출처 및 근거

ORD 기록
ord-49b46472342d45449dddfb46848fa93f
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08895752B2

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