Ammonium formate → HCID 70673729, 화합물

HRID 341332노트

반응식

HRID 341332 반응식
[N+:1]([CH2:4][CH:5]([Si:17]([CH3:20])([CH3:19])[CH3:18])[CH2:6][C:7]([O:9]CC1C=CC=CC=1)=[O:8])([O-])=O.C([O-])=O.[NH4+]>CO.[Pd]>[NH2:1][CH2:4][CH:5]([Si:17]([CH3:18])([CH3:20])[CH3:19])[CH2:6][C:7]([OH:9])=[O:8]

참가 물질

5

반응물 2

HCID 2723923Ammonium formateHCID 70673606HCID 70673606, 화합물

생성물 1

HCID 70673729HCID 70673729, 화합물수율 86%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A suspension of benzyl 4-nitro-3-(trimethylsilyl)butanoate (797 mg, 2.70 mmol) and palladium/carbon (10%, 165 mg) in methanol (30 ml) was added with ammonium formate (1.70 g, 27.0 mmol), and the mixture was stirred under an argon atmosphere for 40 hours. The reaction mixture was filtered through Celite, and the Celite layer was washed with methanol. The reaction mixture was concentrated under reduced pressure, and the residue was purified by recrystallization and silica gel chromatography [methanol (10 to 25%)/chloroform] to obtain 4-amino-3-(trimethylsilyl)butanoic acid (406 mg, 86%) mentioned in the title as colorless powder.

후처리

  1. filtrationThe reaction mixture was filtered through Celite
  2. washthe Celite layer was washed with methanol
  3. concentrationThe reaction mixture was concentrated under reduced pressure
  4. customthe residue was purified by recrystallization and silica gel chromatography [methanol (10 to 25%)/chloroform]

출처 및 근거

ORD 기록
ord-4da1b9521dad4bc6b35897948c716102
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08895769B2

반응 노트

불러오는 중…