Sodium Hydroxide → 4-Chloro-6-methyl-7-(2,5-dihydropyrrol-1-yl-carbonyl)-quinazoline

HRID 34140노트

반응식

HRID 34140 반응식
[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[C:12]([OH:14])=O)[N:8]=[CH:7][NH:6][C:5]2=O.S(Cl)([Cl:18])=O.[NH:20]1[CH2:24][CH:23]=[CH:22][CH2:21]1.[OH-].[Na+]>ClCCl>[Cl:18][C:5]1[C:4]2[C:9](=[CH:10][C:11]([C:12]([N:20]3[CH2:24][CH:23]=[CH:22][CH2:21]3)=[O:14])=[C:2]([CH3:1])[CH:3]=2)[N:8]=[CH:7][N:6]=1

참가 물질

6

반응물 4

HCID 14798Sodium HydroxideHCID 24386Thionyl ChlorideHCID 660593-PyrrolineHCID 136363910HCID 136363910, 화합물

생성물 1

HCID 866326964-Chloro-6-methyl-7-(2,5-dihydropyrrol-1-yl-carbonyl)-quinazoline

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Prepared analogously to Example 2b or 2c from 6-methyl-4-oxo-3,4-dihydro-quinazoline-7-carboxylic acid, thionyl chloride, 2,5-dihydropyrrole, sodium hydroxide solution and dichloromethane.

출처 및 근거

ORD 기록
ord-43e80a9573df46fb99ae35d42496dc0e
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429597B2

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