Water → 4-Bromo-2-fluoro-3-(trifluoromethyl)aniline

HRID 341737

반응식

HRID 341737 반응식
[Br:1]N1C(=O)CCC1=O.[F:9][C:10]1[C:16]([C:17]([F:20])([F:19])[F:18])=[CH:15][CH:14]=[CH:13][C:11]=1[NH2:12].O>CN(C)C=O>[Br:1][C:15]1[CH:14]=[CH:13][C:11]([NH2:12])=[C:10]([F:9])[C:16]=1[C:17]([F:18])([F:19])[F:20]

참가 물질

5

반응물 3

HCID 962WaterHCID 67184N-bromobutanimideHCID 1455693-Amino-2-fluorobenzotrifluoride

생성물 1

HCID 536697144-Bromo-2-fluoro-3-(trifluoromethyl)aniline수율 76.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

A solution of N-bromosuccinimide (24.9 g) in N,N-dimethyl formamide was added to a solution of 2-fluoro-3-trifluoromethylaniline (25 g) in dimethyl formamide. The mixture was stirred for four and a half hours. It was poured into water and the oil was separated. The aqueous layers was extracted with ether and the combined organic layers were washed with water, dried (MgSO4) and filtered. The filtrate was evaporated to dryness and the residue was distilled to give 4-bromo-2-fluoro-3-trifluoromethylaniline (27.44 g) as an orange oil, b.p. 88°-94° C./4 mbar.

후처리

  1. customthe oil was separated
  2. extractionThe aqueous layers was extracted with ether
  3. washthe combined organic layers were washed with water
  4. dry with materialdried (MgSO4)
  5. filtrationfiltered
  6. customThe filtrate was evaporated to dryness
  7. distillationthe residue was distilled

출처 및 근거

ORD 기록
ord-631dc0120bfa4282a8aa156e9f50f95d
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05856274

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